Dealing with Disappointment

This topic seems to come up time and time again in my life. I know life has its share of celebrations and disappointments, but what do you do when you are in a season of disappointments? Disappointments are the most humbling and most profound proof of the existance of God's hand in our lives. It makes me realize that nothing is by chance and nothing happens unless God wills it to happen.

I have been praying for a change in my life for a long time now. I've been burned out with my job mainly. I've been applying and sending out this awesome, tailored cover letter that is so creative and fresh. But that has still led me nowhere and I've gotten several of those rejection emails. 

What do you do? I guess you simply KEEP ON GOING and that is all you can do. You pray for strength and guidance and "just keep truckin."